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Amino Acid Derivative

Dipalmitoyl Hydroxyproline

A skin-conditioning amino acid derivative that helps support collagen, improve firmness and elasticity, smooth the appearance of fine lines, and promote a more supple, youthful-looking complexion.

Key Benefits

  • Supports firmer-looking skin
  • Helps improve suppleness
  • Smooths the look of fine lines
  • Conditions dry skin
  • Complements collagen-focused formulas

How It Works

Hydroxyproline is an amino acid abundant in collagen, while palmitoylation produces an oil-compatible derivative with greater affinity for lipid phases and the skin surface.

The ingredient is proposed to support extracellular-matrix appearance and provide emollient conditioning. However, applying a hydroxyproline derivative does not mean it is directly inserted into new collagen, and topical penetration depends on the delivery system.

Clinical evidence comes mainly from multi-active formulations. A three-month study of one such serum reported improvements in wrinkles, firmness, tone, radiance, and roughness, but the individual effect of Dipalmitoyl Hydroxyproline was not determined.

Ingredient Details

INCI Name: Dipalmitoyl Hydroxyproline

Ingredient Type: Lipidated Amino Acid Derivative

Best For

Mature-looking skin · Skin showing loss of elasticity · Dry or normal skin · Fine lines · Firming-focused routines

What It Is

An oil-soluble derivative of hydroxyproline created by adding two palmitoyl groups. It combines an amino-acid-related structure with fatty chains for use in topical cosmetic systems.

What It Does

Supports a smoother, more supple, and firmer-looking complexion while providing lipid-compatible skin conditioning. Its individual clinical contribution remains difficult to separate from accompanying actives.

Dipalmitoyl Hydroxyproline FAQs

Common questions about this ingredient in skincare.

What is Dipalmitoyl Hydroxyproline?
It is hydroxyproline modified with two palmitoyl fatty chains, creating a lipid-compatible cosmetic conditioning ingredient.
Is it collagen?
No. It is a derivative of an amino acid found abundantly in collagen, but it is not collagen itself.
Does it rebuild collagen directly?
It should not be described as direct replacement collagen. Proposed matrix-support effects are based mainly on supplier research and multi-ingredient formulas.
What visible benefits can I expect?
In a well-formulated product, it may support a smoother, firmer, more supple appearance and improve dry skin feel.
Can it be combined with peptides or retinoids?
Yes. It is often paired with signaling peptides, antioxidants, or retinoids in comprehensive age-supportive formulas.
How strong is the clinical evidence?
Published clinical evidence involves complex serums containing many active ingredients, so the specific contribution of Dipalmitoyl Hydroxyproline remains uncertain.
Shop the ingredient

Products Featuring Dipalmitoyl Hydroxyproline

elvis+elvin Prime Nourishing Eye Oil productelvis+elvin Prime Nourishing Eye Oil product image
Prime Nourishing Eye Oil
السعر بعد الخصمDhs. 421.00
elvis+elvin Rose Lip Serum with Hyaluronic Acid productelvis+elvin Rose Lip Serum with Hyaluronic Acid product image
Rose Lip Serum with Hyaluronic Acid
السعر بعد الخصمDhs. 86.00
elvis+elvin Tsubaki Tinted Hydrating Lip Balm product#color_010 Pale Peach
Tsubaki Tinted Hydrating Lip Balm
السعر بعد الخصمDhs. 103.00